Japanese drugmaker Takeda made its interest in Shire known last month, and its Irish has confirmed today that it has rejected three bids, with the last one working out at £44bn
FTSE 100 gained support from higher metals prices and a slide in sterling on Wednesday to close higher
FTSE 100 closed higher, as did it mid-cap cousin, FTSE 250
The FTSE 100 closed below the 7,200 level as sterling continues to strengthen against the dollar
After an up-and-down day, the FTSE 100 finished in positive territory after a late surge
The UK blue-chip benchmark closed 1.20 points, or 0.02% at 7,258..
FTSE 100 closed in the red - down around nine points at 7,257
Soothing comments from China's leader Xi Jinping seem to have gone down well with equities traders, particularly those in the US
The UK blue chip share index finished around 11 points higher at 7,194
Investors remain nervous over the prospect of an escalating trade war between the US and China but were somewhat placated by anaemic jobs growth in March in the US, which has made four rate rises this year less likely
The UK bluechip-benchmark closed over 165 points higher at 7,199, while the FTSE 250 added over 311 points at 19,576
The blue-chip benchmark closed up around three points at 7,034, with the big cap miners lagging
The pound is up 0.36% against the Euro at the time of writing, while it is up 0.07% against the US dollar
Turnaround group Melrose received valid acceptances for its offer for GKN representing around 52.43% of the voting rights
The UK blue-chip index finished over 44 points higher at 7,044, but big miners tempered gains
In the currency markets, the pound shed 0.17% against the Euro, and lost 0.46% against the US dollar
Sterling added 0.01% against the Euro to 1.1434, while against the US dollar, it added 0.60% to 1.4232.
Will EU leaders approve the Brexit transition deal reached between Michel Barnier and David Davis?
In the currency markets, the pound is up 0.13% against the Euro, but down 0.20% against the US dollar.
The UK's premier index closed down around 22 points at 7,038, while the FTSE 250 shed over 55 points at 19,668.
The Footsie has been in consolidation mode for most of the day
FTSE 100 closed down 121 points at 7,042, joining other European benchmarks, which saw red
The top-share index rallied in the afternoon session to close at 7,164, up 24 points on the day
Britain's blue chip index closed up around seven points, or 0.10%, at 7,139..
FTSE 100 closed down around six points at 7,132 but big cap miners were up